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WEC 53: Henderson vs. Pettis took place on December 16, 2010 at Jobing.com Arena in the Phoenix suburb of Glendale, Arizona. The was be the first event that Zuffa has hosted in Arizona.
This was the final WEC event as the promotion has merged with the Ultimate Fighting Championship in 2011. The WEC Bantamweight Champion will be recognized as the UFC Bantamweight Champion. The WEC Lightweight Champion will face the winner of UFC 125’s Frankie Edgar-Gray Maynard bout in a superfight to unify the WEC and UFC lightweight championships.
WEC 53 Post Fight Videos
WEC 53 Retrospective
| Match | Winner | Loser | Method | Round | Time |
| 1 | Renan do Nascimento Mota Pegado | Chris Cariaso | Submission (Rear-Naked Choke) | 1 | 3:47 |
| 2 | Yuri Alcantara | Ricardo Lamas | KO (Punches) | 1 | 3:26 |
| 3 | Danny Castillo | Will Kerr | KO (Punches) | 1 | 1:25 |
| 4 | Eddie Wineland | Ken Stone | KO (Slam) | 1 | 2:11 |
| 5 | Brad Pickett | Ivan Menjivar | Decision (Unanimous) | 3 | 5:00 |
| 6 | Shane Roller | Jamie Varner | Submission (Rear-Naked Choke) | 1 | 3:55 |
| 7 | Daniel Downes | Tie Quan Zhang | Decision (Unanimous) | 3 | 5:00 |
| 8 | Kamal Shalorus | Bart Palaszewski | Decision (Split) | 3 | 5:00 |
| 9 | Donald Cerrone | Chris Horodecki | Submission (Triangle Choke) | 2 | 2:43 |
| 10 | Dominick Cruz | Scott Jorgensen | Decision (Unanimous) | 5 | 5:00 |
| 11 | Anthony Pettis | Benson Henderson | Decision (Unanimous) | 5 | 5:00 |
