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Strikeforce: Feijao vs. Henderson, also known as Strikeforce: Columbus took place on March 5, 2011 at the Nationwide Arena in Columbus, Ohio, United States. The event was the first that the organization has hosted in the state of Ohio and will coincide with the Arnold Sports Festival, which annually draws up to 150,000 sports fans.
According to officials Strikeforce scored an attendance of 7,123 and averaged 412,000 viewers on Showtime.
Strikeforce: Feijao vs. Henderson Post Fight Analysis
Strikeforce: Feijao vs. Henderson Tapology
Strikeforce: Feijao vs. Henderson Pre-Fight Analysis
| Match | Winner | Loser | Method | Round | Time |
| 1 | John Kuhner | John Felty | Technical Submission (Triangle Choke) | 2 | 4:31 |
| 2 | Mitch Whitesel | Marc Cofer | Submission (Guillotine Choke) | 1 | 3:55 |
| 3 | Brian Rogers | Ian Rammel | TKO (Punches) | 1 | 4:23 |
| 4 | Jay Freeman | Jason Riley | Submission (Punches) | 1 | 1:52 |
| 5 | Jorge Gurgel | Billy Vaughan | Submission (Guillotine Choke) | 1 | 0:44 |
| 6 | Roger Bowling | Josh Thornburg | Decision (Unanimous) | 3 | 5:00 |
| 7 | Jorge Masvidal | Billy Evangelista | Decision (Unanimous) | 3 | 5:00 |
| 8 | Tim Kennedy | Melvin Manhoef | Submission (Rear-Naked Choke) | 1 | 3:41 |
| 9 | Marloes Coenen | Liz Carmouche | Submission (Triangle Choke) | 4 | 1:29 |
| 10 | Dan Henderson | Rafael Cavalcante | TKO (Punches) | 3 | 0:50 |
