Strikeforce: Melendez vs. Thomson was promoted by Strike Force. The event took place at the HP Pavilion in San Jose, California on Friday, June 27, 2008.
The main event was the long awaited match between lightweights Gilbert Melendez and Josh Thomson for the Strikeforce Lightweight title.
| Match | Winner | Loser | Method | Round | Time |
| 1 | Alexandre Trivino | Eric Jacob | Submission (Armbar) | 1 | 0:37 |
| 2 | Jorge Interiano | Travis Johnson | TKO (Doctor Stoppage) | 2 | 3:00 |
| 3 | Cyrillo Padhillo | Jesse Jones | Decision (Unanimous) | 3 | 3:00 |
| 4 | Brian Caraway | Alvin Cacdac | Submission (Rear-Naked Choke) | 1 | 1:39 |
| 5 | Bobby Stack | Jose Palacios | Decision (Unanimous) | 3 | 3:00 |
| 6 | Chris Cariaso | Anthony Figueroa | Submission (Rear-Naked Choke) | 2 | 4:34 |
| 7 | Jeremiah Metcalf | Raymond Daniels | Submission (Rear-Naked Choke) | 2 | 0:59 |
| 8 | Miesha Tate | Elaina Maxwell | Decision (Unanimous) | 3 | 3:00 |
| 9 | Bobby Southworth | Anthony Ruiz | Decision (Unanimous) | 5 | 5:00 |
| 10 | Billy Evangelista | Nam Phan | Decision (Split) | 3 | 5:00 |
| 11 | Josh Thomson | Gilbert Melendez | Decision (Unanimous) | 5 | 5:00 |
| 12 | Eric Lawson | Jesse Gillespie | Submission (Rear-Naked Choke) | 1 | 1:03 |
