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WEC 43: Cerrone vs. Henderson took take place on October 10, 2009 at the AT&T Center in San Antonio, Texas. The event was scheduled to take place on September 2, 2009 at the Covelli Centre in Youngstown, Ohio. However, due to headline Ben Henderson having eye surgery, the event was later rescheduled.
WEC 43: 10 Things I Learned Last Night
Picks and Predictions for WEC 43: Save a Horse, Ride a Cowboy
| Match | Winner | Loser | Method | Round | Time |
| 1 | Deividas Taurosevicius | Javier Vazquez | Decision (Split) | 3 | 5:00 |
| 2 | Charlie Valencia | Coty Wheeler | Decision (Unanimous) | 3 | 5:00 |
| 3 | Eddie Wineland | Manny Tapia | Decision (Unanimous) | 3 | 5:00 |
| 4 | Mackens Semerzier | Wagnney Fabiano | Submission (Triangle Choke) | 1 | 2:14 |
| 5 | Scott Jorgensen | Noah Thomas | TKO (Punches and Elbows) | 1 | 3:13 |
| 6 | Anthony Njokuani | Muhsin Corbbrey | TKO (Punches) | 2 | 1:42 |
| 7 | Damacio Page | Will Campuzano | Submission (Rear-Naked Choke) | 1 | 1:02 |
| 8 | Raphael Assuncao | Yves Jabouin | Decision (Split) | 3 | 5:00 |
| 9 | Dave Jansen | Rich Crunkilton | Decision (Unanimous) | 3 | 5:00 |
| 10 | Benson Henderson | Donald Cerrone | Decision (Unanimous) | 5 | 5:00 |
WEC 43 featured some very exciting fights, but it was hindered by some lopsided matchups (Yves Jabouin, Will Campuzano, Noah Thomas). Why couldn't we see Damacio Page vs. Scott Jorgensen? Mackens Semerzier gets a pass since he did pull off the upset.