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UFC 106: Ortiz vs. Griffin 2 was held on November 21, 2009 in Las Vegas, Nevada at the Mandalay Bay Events Center.
UFC 106 Previews, Picks & Predictions
| Match | Winner | Loser | Method | Round | Time |
| 1 | George Sotiropoulos | Jason Dent | Submission (Armbar) | 2 | 4:36 |
| 2 | Caol Uno | Fabricio Camoes | Draw (Majority) | 3 | 5:00 |
| 3 | Brian Foster | Brock Larson | Submission (Punches) | 2 | 3:25 |
| 4 | Kendall Grove | Jake Rosholt | Submission (Triangle Choke) | 1 | 3:59 |
| 5 | Ben Saunders | Marcus Davis | KO (Knees) | 1 | 3:24 |
| 6 | Amir Sadollah | Phil Baroni | Decision (Unanimous) | 3 | 5:00 |
| 7 | Antonio Rogerio Nogueira | Luis Arthur Cane | TKO (Punches) | 1 | 1:56 |
| 8 | Paulo Thiago | Jacob Volkmann | Decision (Unanimous) | 3 | 5:00 |
| 9 | Josh Koscheck | Anthony Johnson | Submission (Rear-Naked Choke) | 2 | 4:47 |
| 10 | Forrest Griffin | Tito Ortiz | Decision (Split) | 3 | 5:00 |
Karo Parisyan has withdrawn from his fight with Dustin Hazelett the day before weigh ins and was subsequently cut from the UFC.
