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WEC 45: Cerrone vs. Ratcliff took place on December 19, 2009 at The Pearl at The Palms in Las Vegas, Nevada. This marks the first time the WEC had held back-to-back events at the The Pearl at The Palms.
WEC 45 Previews, Picks & Predictions
| Match | Winner | Loser | Method | Round | Time |
| 1 | Erik Koch | Jameel Massouh | Decision (Unanimous) | 3 | 5:00 |
| 2 | Brad Pickett | Kyle Dietz | Submission (Peruvian Necktie) | 2 | 4:36 |
| 3 | Brandon Visher | Courtney Buck | TKO (Punches) | 1 | 4:45 |
| 4 | Chad George | John Hosman | Decision (Unanimous) | 3 | 5:00 |
| 5 | Zachary Micklewright | Muhsin Corbbrey | Decision (Unanimous) | 3 | 5:00 |
| 6 | Bart Palaszewski | Anthony Pettis | Decision (Split) | 3 | 5:00 |
| 7 | Scott Jorgensen | Takeya Mizugaki | Decision (Unanimous) | 3 | 5:00 |
| 8 | Joseph Benavidez | Rani Yahya | TKO (Punches) | 1 | 1:35 |
| 9 | Anthony Njokuani | Chris Horodecki | TKO (Head Kick and Punches) | 1 | 3:33 |
| 10 | Donald Cerrone | Ed Ratcliff | Submission (Rear-Naked Choke) | 3 | 3:47 |
