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UFC 122: Marquardt vs. Okami took place on November 13, 2010 at König Pilsener Arena in Oberhausen, Germany. This event aired on Spike TV in the U.S via tape delay.
An illness forced Alessio Sakara out of his co-main event bout with Jorge Rivera while the preliminary fights were taking place. The fight was scrapped from the card. The fight between Duane Ludwig and Nick Osipczak was promoted to the co-main event.
UFC 122 Reviews & Commentary
UFC 122 Previews & Predictions
| Match | Winner | Loser | Method | Round | Time |
| 1 | Carlos Eduardo Rocha | Kris McCray | Submission (Kneebar) | 1 | 2:21 |
| 2 | Karlos Vemola | Seth Petruzelli | TKO (Punches and Elbows) | 1 | 3:46 |
| 3 | Kyle Noke | Rob Kimmons | Submission (Rear-Naked Choke) | 2 | 1:33 |
| 4 | Pascal Krauss | Mark Scanlon | Decision (Unanimous) | 3 | 5:00 |
| 5 | Vladimir Matyushenko | Alexandre Ferreira | TKO (Punches and Elbows) | 1 | 2:20 |
| 6 | Duane Ludwig | Nick Osipczak | Decision (Split) | 3 | 5:00 |
| 7 | Krzysztof Soszynski | Goran Reljic | Decision (Unanimous) | 3 | 5:00 |
| 8 | Amir Sadollah | Peter Sobotta | Decision (Unanimous) | 3 | 5:00 |
| 9 | Dennis Siver | Andre Winner | Submission (Rear-Naked Choke) | 1 | 3:37 |
| 10 | Yushin Okami | Nate Marquardt | Decision (Unanimous) | 3 | 5:00 |
