DREAM.4 Middle Weight Grandprix 2008 2nd Round was held by FEG’s mixed martial arts promotion DREAM. The event took place on June 15, 2008 at Yokohama Arena in Yokohama, Japan, featuring the second round of the promotion’s Middleweight tournament, with winners advancing to the DREAM Middleweight GP Final at the Saitama Super Arena on September 23, 2008.
During the evening’s intermission, a draw was held in the ring to determine the matchups for the July 21, 2008 DREAM Lightweight GP Final in Osaka. The random selection set Eddie Alvarez against Tatsuya Kawajiri in the first semifinal; and Shinya Aoki against Caol Uno in the second.
The DREAM.4 attracted a crowd of 14,037 to the Yokohama Arena and was broadcast live in Japan on SkyPerfect TV Pay-Per-View, and in the United States on HDNet Fights.
| Match | Winner | Loser | Method | Round | Time |
| 1 | Shinya Aoki | Katsuhiko Nagata | Submission (Gogoplata) | 1 | 5:12 |
| 2 | Alistair Overeem | Tae Hyun Lee | KO (Punches) | 1 | 0:36 |
| 3 | Ralek Gracie | Alavutdin Gadzhiyev | Submission (Armbar) | 1 | 3:02 |
| 4 | Hideo Tokoro | Darren Uyenoyama | Decision (Unanimous) | 2 | 5:00 |
| 5 | Gegard Mousasi | Dong Sik Yoon | Decision (Unanimous) | 2 | 5:00 |
| 6 | Zelg Galesic | Taiei Kin | TKO (Elbow Injury) | 1 | 1:05 |
| 7 | Ronaldo Souza | Jason Miller | Decision (Unanimous) | 2 | 5:00 |
| 8 | Melvin Manhoef | Kazushi Sakuraba | TKO (Punches) | 1 | 1:30 |
