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UFC Fight Night 22: Marquardt vs. Palhares was held on September 15, 2010 at the Frank Erwin Center in Austin, Texas. The event preceded the season premiere of The Ultimate Fighter: Team GSP vs. Team Koscheck.
UFC Fight Night 22 Post Fight Videos
UFC Fight Night 22 Previews & Predictions
| Match | Winner | Loser | Method | Round | Time |
| 1 | Brian Foster | Forrest Petz | TKO (Punches) | 1 | 1:07 |
| 2 | Anthony Waldburger | David Mitchell | Decision (Unanimous) | 3 | 5:00 |
| 3 | Rich Attonito | Rafael Natal | Decision (Unanimous) | 3 | 5:00 |
| 4 | Dave Branch | Tomasz Drwal | Decision (Unanimous) | 3 | 5:00 |
| 5 | Kyle Kingsbury | Jared Hamman | Decision (Unanimous) | 3 | 5:00 |
| 6 | Yves Edwards | John Gunderson | Decision (Unanimous) | 3 | 5:00 |
| 7 | Cole Miller | Ross Pearson | Submission (Rear-Naked Choke) | 2 | 1:49 |
| 8 | Jim Miller | Gleison Tibau | Decision (Unanimous) | 3 | 5:00 |
| 9 | Charles Oliveira | Efrain Escudero | Submission (Rear-Naked Choke) | 3 | 2:25 |
| 10 | Nate Marquardt | Rousimar Palhares | TKO (Punches) | 1 | 3:28 |
